Tadalafil (Oral Tablet): Side Effects, Dosage, and Review
Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective. Tell your doctor about all your other medicines, especially: medicine to treat erectile dysfunction (impotence) or pulmonary arterial hypertension-riociguat, bosentan, avanafil, sildenafil, or vardenafil; Systemic drug exposures, as measured by AUC of unbound tadalafil, were approximately 5 fold for mice, and fold for male and female rats, respectively, the exposures at the maximum recommended human dose (MRHD) of 40 mg. Mutagenesis Tadalafil was not mutagenic in the in vitro bacterial Ames assays or the forward mutation test Tadalafil USP is white or almost white powder that is freely soluble in dimethyl sulfoxide, slightly soluble in methylene chloride, practically insoluble in water. Tadalafil tablets, USP are available as white color, capsule shaped, film-coated tablets for oral administration. tadalafil drug class Tadalafil helps men with erectile dysfunction (ED). When taken as needed for ED, one dose can work up to 36 hours. It can also treat signs/symptoms of benign prostatic hyperplasia. Alpha-Blockers ED When tadalafil tablets are coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and tadalafil tablets should be initiated at the lowest recommended dose [see Warnings and Precautions ( 5.6), Drug Interactions ( 7.1), and
Tadalafil AUC after a 10 mg dose in patients with mild or moderate hepatic impairment (Child-Pugh class A or B) was comparable with exposure in healthy subjects. There are insufficient data for subjects with severe hepatic impairment. Special Populations: Elderly
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